September 2016 SPSFAM Book

j Monitoring Data for Veterinary Drug Residues

Overall, non‐compliance is steady or decreasing

Analytical Strategy

 Aim is to check if samples are below or potentially above the Screening Target Concentration (STC)  Results are either < STC  (given in µg/kg) or Suspect  Response = relative comparison between Peak Area in Unspiked Sample (A us ) vs. Peak Area in the related Spiked Sample (A s )

Validation scheme according to EU CRL 2010 / 01 / 20

Milk‐based products Milk fractions (16), infant 

67 samples Fortified at 0, 1, 2 STC Three analysts involved O 15 d ver  ays

Cut‐off level False suspect rate: < 10% False negative rate: < 5% R i i 0 2 i etent on t me: < . m n Identification: 2 MRM

formulae & milk powders (15),  milk‐based infant cereals (5)

Design

Samples

Meat/Seafood products Meat/seafood powders (10),  Meat /seafood fresh and  cooked (10), meat‐based baby‐ foods

ity Criteria

Qual

Full validation by the developing lab + Multi-site implementation (France, Singapore, USA)