LIT-PX120 - Pharmaceutical Industry

Chromalox ® PRECISION HEAT AND CONTROL

Precise Heating Solutions for the Pharmaceutical Industry

ASSURING YOUR PROCESS PERFORMANCE WITH CHROMALOX

CHROMALOX HAS YOUR HEAT AND CONTROL SOLUTIONS

ADDED

With the broadest product line in the industry, Chromalox provides

VALUE precision heat and control systems for more processes than anyone in the world. We provide solutions for industries as diverse as transportation, petrochemical, power generation, the military, . . . and pharmaceuticals.

The Chromalox Difference Some companies build heaters and controls. Chromalox does more. We provide value-added heating solutions throughout pharmaceutical plants. The difference between these two approaches is the difference between uncertainty and assurance. It’s the difference between having a supplier who just sells equipment and having a partner who can help you save time and money even before startup, who works with you to maximize process efficiency and minimize downtime, and who provides the field service and technical support to get the

job done. That’s value-added. And you get it from Chromalox.

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TECHNOLOGIES THAT REFLECT AN UNDERSTANDING OF PHARMACEUTICALS PROCESSING

PRODUCTS CHROMALOX HAS A LONG HISTORY OF INNOVATION IN THE PROCESSING INDUSTRIES Chromalox has been developing better means of applying electrical heat for a variety of processing industries since 1915. That year, we introduced the world’s first metal-sheathed heating element.

Chromalox Understands Every Facet of the Process

From circulation heaters for process water applica- tions to self-regulating heat trace cable and controls that maintain process temperature. From hot oil systems for heating reactor vessels to high-purity immersion heaters for stainless steel storage tanks. Plus package systems for heating and cooling on dryers, mixers, and columns. Our expertise, combined with the most stringent material and manufacturing standards you’ll find in the industry, provides you with an array of products you can count on to perform at each critical process phase. Chromalox Meets Your Specific Challenges With that kind of experience behind us, Chromalox understands the unique challenges that pharma- ceutical plant builders, managers, and maintenance personnel face. And we have the knowledge, experience base, local support, and technical skills to meet those challenges with you.

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Reactor Temperature Control Thermal fluid heat transfer systems provide heating and cooling for various reactions which require tight temperature control.

Process Air Heating Circulation and air duct heaters heat incoming air streams for a variety of drying requirements.

In-Line Heating Circulation heaters heat flowing liquids and gases. Chromalox offers custom and sanitary designs.

Transfer Lines Electric heat trace provides pipe temperature maintenance for temperature-sensitive materials. Chromalox offers self-regulating cable and control systems for general- purpose and hazardous locations. Mineral- insulated and constant-wattage cables are also available.

PHARMACEUTICAL The growth of the biotechnology and pharmaceutical industries has been paralleled by the growth of another industry– bioprocessing. Chromalox understands the unique challenges of the processes involved in the creation, testing, and production of pharmaceutical products. Immersion Heaters Stainless steel sheath elements and thermowells are ideal for process water applications. A wide variety of ANSI and customized flanges and element lengths is available with ratings up to 500 kW. Custom watt densities available for heat- sensitive materials. Sanitary designs available. A patented 360º rotatable housing is available on screw plug models for easy conduit connections. Class 1, Division 1 rated. Circulation Heaters High-energy efficiency, fast heating, and uniform heat distribution for numerous plant heating applications. High turn-down capability, tight outlet temperature control, and variable flow rates. Custom watt densities available for heat-sensitive materials. Sanitary designs available. Variety of electrical terminal enclosures available to meet the requirements of your application. Class 1, Division 1 rated. and ready to install, needing only a water feed-source and electric power hook-up to Ingredient Tank Heaters Immersion heaters keep ingredients warm before being introduced to the manufacturing process. Chromalox LTFX model immersion heaters are ideal because tanks do not need to be drained to replace the heating element. RO Preheater Circulation and immersion heaters preheat incoming water to help reverse osmosis machines operate more efficiently.

Electric Steam Boilers Constructed of carbon or stainless

steel with fiberglass insulation to ASME or PED code. Safe, versatile, and efficient energy management systems that provide low- or high-pressure hot water or steam. Packaged units are completely assembled

operate from existing distribution voltages, making installation simple. Class 1, Division 1 rated.

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Mixing and Drying TCUs and packaged boilers provide heating/ cooling for jacketed mixers and shelf dryers.

Sterilization Boilers can be used for direct sterilization of pharmaceutical containers.

CIP and SIP Systems Immersion and circulation heaters are used to heat water and cleaning solutions for sterilization and cleaning applications.

Comfort Heating Comfort heaters for work stations and room temperature control. Hazardous and non- hazardous area designs available.

PHARMACEUTICAL Whether you are designing a pilot plant or looking for production-scale pharmaceutical equipment, Chromalox can help you optimize your ancillary equipment to keep your total installed costs to a minimum. Our equipment is used as part of the basic support equipment for • Purified gas and air delivery • Purified water • Chemical delivery • Steam and gas injection systems • Control equipment for monitoring and logging process temperatures • Reactor process control

Steam Superheaters Used to “clean” steam that has accumulated excess moisture, Chromalox steam superheaters are also used in a variety of other drying applications.

Solvent Recovery Immersion, circulation, and heat transfer systems heat distillation columns and evaporators.

Pharmaceutical Packaging Tubular, strip, and cartridge heating elements heat sealing on pharmaceutical packaging machinery.

Heat Transfer Systems Our hot oil and water/glycol systems are safe, versatile, user-friendly self-contained heating and cooling packages that provide direct or indirect process heating. Pre- engineered and constructed with carefully matched components, these systems eliminate component

Heat Trace and Controls Counteracts the heat loss from process equipment and piping, prevents solution precipitation and the increase of viscosity or solidification of product, and provides freeze protection. Chromalox offers a variety of heat trace cable; temperature control, monitoring, and management in one, modular package; and all of the necessary

Control Systems Basic, low-cost temperature and process controllers; monitors and overtemperature controls; sophisticated control systems. Chromalox can design the right system

for your plant’s needs including integration with DCS and PLC programs. We are the only heating element supplier offering a complete line of controls, control panels, and accessories.

selection and assembly, and provide easy install- ation and trouble-free operation.

components needed to complete the installation, including splices, power connection boxes, and water-resistant end-seal terminations. Class 1, Division 1 rated.

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UNRIVALED DESIGN AND ENGINEERING CAPABILITIES FOCUSED ON YOUR COMPLETE HEAT AND CONTROL SOLUTION

Comprehensive Engineering Capabilities Focused on Your Application Our complete engineered systems • Reduce installation labor • Shorten startup time • Ensure proper operation to specification

Resources to Help Save You Time and Money

Our in-house engineering and software capabilities allow us to design user-friendly interfaces. These advanced designs can reduce your business train- ing time and expense, as well as increase repeat- able operation. In addition, Chromalox has training tools and resources to assist you with installation, startup, and operation. Among the software Chromalox employs are: • Finite element analysis by Cosmo Works • AutoCAD, Inventor, and 3D Solid Works • AutoCAD electrical drawing scanning and rastering capability • COADE for ASME, wind, and seismic loading • HTFS heat exchanger dynamic modeling • PLC programming and testing

DESIGN AND ENGINEERING BENCHMARKS OF THE INDUSTRY’S DESIGN AND ENGINEERING LEADER • Chromalox introduced the world’s first metal- sheathed heating element over 90 years ago • Chromalox engineers 3,600 unique, new products every year • Chromalox has more than 700,000 customer designs on record • Chromalox in-house lab certifies products for both CSA and UL requirements More than 75 Chromalox engineers–including UL- and CSA-certified professionals–are avail- able and ready to help you integrate our products into your application and achieve these benefits. At their disposal is our full range of engineering capabilities, including: • Application expertise • Heating technology selection • Feasibility and detailed design of process loads and systems • Design for skids or packages • Safe or hazardous area selection • Heat transfer design using the latest software • Materials selection • Pressure vessel design • Mechanical and electrical design • Control and instrumentation system design • Project engineering management

Follow-Through with Complete On-Site Engineering Service and Support Chromalox provides highly qualified personnel for site commissioning and operational servicing anywhere in the world. Our engineers are exten- sively trained for onshore and offshore facilities and possess the required medical and safety certifications. They can commission the mechani- cal, electrical, instrumentation, and control equipment for any system we build. Custom Design for Special Needs Chromalox can design heating solutions for any unique requirement. Our engineers will custom- design the right product to meet your application needs. Drawing on the more than 700,000 top- level designs we have on file, we will design an existing product or design and manufacture a completely new one to fit your needs. Chromalox will help you produce prototypes for new prod- ucts and systems, developing innovative design in the shortest possible turnaround time.

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ELECTRIC HEAT OFFERS SIGNIFICANT BENEFITS AND ADVANTAGES OVER OIL- OR GAS-FIRED SYSTEMS

There are a lot more “green” reasons beyond environmental concerns to choose electric heat over oil- and gas-fired heat systems. Electric heat offers a number of advantages that can benefit manufacturers in saving or reducing manufacturing, installation, operating, maintenance, and capital costs. Improved safety and the ability to meet or exceed regulatory issues are important considerations, too.

Consistent Pricing Electric utility prices have been very consistent, averaging only 4% yearly increases. This allows customers to accurately determine operating cost without gambling on the volatile prices of gas or oil. Gas and oil prices tend to be erratic, with prices surging every winter. Clean Running Operation With electric heat there is no additional expense of installing exhaust piping, fuel or gas inlet lines, storage tanks for fuel oil, or air inlet lines–not to mention the factory space lost to accommodate such a system. No Pollution Electric converts 100 percent of the power input into heat energy with no pollutants generated. Fuel- and gas-fired systems produce pollutants that must be monitored and controlled in accor- dance with EPA regulations. Quiet Operation Electric heaters have no combustion noise and minimal moving parts. This greatly reduces con- cerns over meeting OSHA noise regulations. Reduced Footprint and Envelope Size Compared to some similar oil and gas heating systems of similar outputs, electric heaters are typically one-quarter to one-half the size.

Minimal Maintenance Due to the simpler operations of electric heaters (i.e., no combustion controls) very little mainte- nance is needed. In addition, electric elements can be easily replaced by service personnel. Lower Operating Cost Due to the complexity of controlling a fuel/air mixture in a fuel or gas system, a full-time, trained technician may be needed for its opera- tion. In addition, without continual tuning, gas and oil units can have reduced efficiencies. Safety Concerns Electric heaters have no open flames. Flame- operated systems may require installation away from any potentially combustible areas. Large Turndown / Precise Control With multiple staging or an SCR power control, electric heaters can respond rapidly and precisely to varying process conditions for operating cost savings. The large turndown ratios possible with electric heat drop operating costs proportionally, while turndown ratios of other heat technologies, e.g. steam, deliver a diminishing return of operating cost reduction.

OIL AND GAS

BENEFITS OVER

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Chromalox Value-Added Products and Services Are Available Worldwide

Chromalox ® PRECISION HEAT AND CONTROL

103 Gamma Drive Pittsburgh, PA 15238

Phone: (412) 967-3800 Fax: (412) 967-5148 Toll-Free: 1-800-443-2640

email: sales@chromalox.com

www.chromalox.com

USA

Chromalox-UK

Tel: +44 (0)20 8665 8900 Fax: +44 (0)20 8689 0571

email: uksales@chromalox.com

Unit 122, Lombard House 2 Purley Way Croydon, Surrey, CR0 3JP, UK

www.chromalox.co.uk

Chromalox-France

Tel: +33 (0)3 23 74 39 39 Fax: +33 (0)3 23 74 39 00

email: etirexchromalox@wanadoo.fr

Route de Château-Thierry

www.chromalox.fr

Noyant et Aconin F-02203 SOISSONS Cedex, France

email: shanghai.office@chromalox.com

Chromalox-China

Tel: +86 (0)21 5866-8802 Fax: +86 (0)21 5866-8803

www. chromalox.cn

Chromalox (Shanghai) Precision Heat and Control Co., Ltd. Suite A2, 4th Floor, Fenggu Building 88 Taigu Road Waigaoqiao Free Trade Zone Shanghai 200131 People’s Republic of China

PX120

Copyright © 2008, Chromalox, Inc.