Upper GI 2017

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Oesophageal Adenocarcinoma CROSS Study Comparison

MAGIC 1 - 2006 Periop. chemo (n=503)

FNCLCC 2 - 2011 Periop. chemo (n=224)

OE-2 3 - 2009 Pre-op. chemo (n=802)

CROSS 4 - 2015 Chemorad. (n=275)

ECF SURG CF SURG CF SURG RCTx SURG

HR=0.75 (95% CI 0.60; 0.93)

HR=0.73 (95% CI 0.55; 0.98)

HR=0.69 (95% CI 0.50; 0.96)

HR=0.84 (95% CI, 0.72; 0.98)

CI: Confidence Interval; CF: Cisplatin, 5-FU; ECF: Epirubicine, Cisplatin, 5-FU; RCTx: Chemoradiation, SURG: Surgery

4 Shapiro J et al., Lancet Oncol 2015

3 Allum B et al., J Clin Oncol 2009

1 Cunningham D et al., NEJM 2006

2 Ychou M et al., J Clin Oncol 2011