Upper GI 2017

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Oesophageal CA – neo Chemoradiation or Chemo?

Neoadjuvant R-CTX 40,0 Gy (20 x 2Gy) Cisplatin 100mg/m²d1 + 5FU 750mg/m² d1-5 x3 RESECTION

R A N D O M

N=180

T1N1M0 or T2–3N0–1M0

Primary endpoint: Histologic complete response (pCR)

AC* SCC**

Neoadjuvant CTX Cisplatin 100mg/m²d1 + 5FU 750mg/m² d1-5 x3 RESECTION

*AC: Adenocarcinoma (73%) **SCC: Squamous cell cancer (27%)

Klevebro F et al., Ann Oncol 2016; 27: 660-667