Upper GI 2017

Molecular features: Main distribution/differences gastric adenocarcinoma:

1) Chromosomal instable (CIS) 49,8% 2) Microsatellite-instable (MSI) 21,7%

3) Genomic stable (GS) 19,6% 4) EBV-induced (EBV) 8,9 %

esophageal adenocarcinoma: 1) EAC = CIS ERBB2 amplification (like in gastric carcinoma)

2) MSI and EBV very rare

From: Cancer Genome Atlas Research Network Group: 1) Integrated molecular characterization of esophageal carcinoma, Nature 2017 2) Epstein-Barr Virus Infection and Mismatch Repair Deficiency in Esophageal Cancer: Clinical Implication for Potential Treatment with PD1/PD-L1 Blockade Therapy; L.C. Hewitt, I.Z Inam, A. Quaas…. and H.Grabsch

Institute of Pathology | Alexander Quaas

Gastrointestinal Cancer Group Cologne (GCGC)