Upper GI 2017
3/28/2017
Overall survival
Dutch Trial THO vs TTO
3-year survival (95% CI) CF 39% (35%, 44%) ECX 42% (37%, 46%) OE02 CS 31% (27%, 36%)
1.00
CF
ECX
OE02CS
– TTO
0.75
– More nodes – More respiratory complications – Lower oesophageal and LN 1-8 better outcome
0.50
0.25
Proportion surviving
0.00
0 1 2 3 4 5 6 7 8 Time from randomisation (Years)
CF At risk
446 343 229 172 124 451 345 227 167 121
70 91 71
50 70 46
38 45 21
27 23 13
ECX
OE02CS
400 235 154 120
85
Alderson,Cunninghamet al ASCO 2015
Survival after TTO vs THO for Type II Tumours
Survival of ALL Px
100
THO 2-Stage RMH
75
50
25
Percent survival
0 365 730 1095 1460 1825 2190 2555 2920 3285 3650 0
MedianSurvival
Survival
RMH 54months THO 49months 2ST 34months P< 0.0005
SurvivalofTHOvs2-ST ALLT1-2N+:Survivalproportions
SurvivalofTHOvs 2-ST ALLT1-2N0:Survivalproportions
SurvivalofTHOvs2-ST ALLN1:Survivalproportions
SurvivalofTHOvs2-ST N0:Survivalproportions
100
100
100
THO 2Stage
THO 2Stage
100
THON1 2-STN1
THON0 2-STN0
75
75
75
75
50
50
50
50
25
25
25
Percent survival
25
Percent survival
Percent survival
Percent survival
0 365 730 109514601825 21902555 29203285 3650 0
0 365 730 1095 14601825 2190 2555 2920 3285 3650 0
0 365 730 1095 1460 1825 2190 2555 2920 3285 3650 0
0 365 730 1095 1460 1825 2190 2555 2920 3285 3650 0
Survival
Survival
Survival
Survival
SurvivalofTHOvs2-ST ALLT3-4N+:Survivalproportions
SurvivalofTHOvs2-ST ALL T3-4N0:Survivalproportions
SurvivalofTHO vs 2-ST ALL N2:Survivalproportions
SurvivalofTHO vs 2-ST ALL N3:Survivalproportions
100
100
THO 2Stage
THO 2Stage
100
100
THON2 2-STN2
THON3 2-STN3
75
75
75
75
50
50
50
50
25
25
Percent survival
Percent survival
0 365 730 109514601825 21902555 29203285 3650 0
25
25
0 365 730 1095 1460 1825 2190 2555 2920 3285 3650 0
Percent survival
Percent survival
Survival
Survival
0 365 730 1095 1460 1825 2190 2555 2920 3285 3650 0
0 365 730 1095 1460 1825 2190 2555 2920 3285 3650 0
Survival
Survival
P= ns
P= ns
12
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