Upper GI 2017

 Preoperative Chemoradiation  Planned Esophagectomy

 Preoperative Chemoradiation  Planned Esophagectomy

EQD2

Tumor site

N. Histology

• Walsh et al – 1996

Cardia 36% 113 pts Adeno 100% EQD2: 42.33 Gy

Mid-Distal 92% 100 pts Adeno 75%

EQD2: 48.75 Gy

• Urba et al – 2001

Mid-Distal 79% 256 pts Adeno 62%

• Burmeister et al – 2005

EQD2: 36.17 Gy

EQD2: 49.56 Gy

Low third n.a.

56 pts Adeno 75%

• Tepper et al – 2008

Junction 24% 366 pts Adeno 75% EQD2: 40.71 Gy

• CROSS - 2015

Statistically in favour of Preop ChemoRT

Mod from Cellini et al ; Radiat Oncol 2014 (Italy)