Upper GI 2017

 Preoperative Chemoradiation  Planned Esophagectomy

• Propensity score match

442 ptz available multi-center (10 Europe)

resectable Esophageal or GEJ Siewert type I and II (stage II or III), adenocarcinoma 100%

• ypT0 = NCR+S= 26 .7% versus NC+S= 5%; p <0.001 ; • R1/2 resection margins = NCR+S= 7.7% versus NC+S= 21.8 %; p < 0.001 ;

• ypN 0 = NCR+S= 63 .3% versus NC+S= 32.1%; p < 0.001 ; • lymph node harvest = NCR+S= 14% versus NC+S= 27 %; p < 0.001 ;

• 30+90-day mortality = No sign diffs • anastomotic leak = NCR+S= 2 3. 1% versus NC+S= 6.8 %; p < 0.001 ;

Evaluation period 2001-2012; follow-up until 2015

Markar SR et al – Ann Oncol - 2016 (Ireland)