Upper GI 2017

 Definitive Chemoradiation  Salvage Esophagectomy

• RTOG 85-01 – 1999 • RTOG 85-01 - 1999

Phase III Trial RT (64Gy) vs RTCT (50Gy)

T1-3 N0-1M0

Low third: n.a.

• RTOG 85-01 – 1999

129 pts

Adeno 21.4%

• RTOG 85-01 – 1999

SVV Benefit (RTCT vs RT Alone)

50 Gy- EQD2: 49.17 Gy

• INT 0123 - 2002

Phase III Trial RTCT (50Gy) vs RTCT (65Gy)

• INT 0123 – 2002 • INT 0123 – 2002

T1-T4 N0-1M0

Low third: n.a. Hystotype: n.a.

218 pts

• INT 0123 – 2002

NO SVV Benefit

Cooper et al ; - JAMA – 1999 Minsky et al; JCO 2002

USA