Upper GI 2017

State of art of radiation therapy in Esophageal Cancer

 Preoperative Chemoradiation  Planned Esophagectomy • Walsh et al – 1996 (Trimodality)

Phase III Trial Chir ± Preop RTCT Phase III Trial Chir ± Preop RTCT

• CROSS - 2015 (Trimodality) • FFCD 9901 - 2014 (Trimodality) • POET - 2009 (Trimodality) • Urba et al – 2001 (Trimodality) • Burmeister et al – 2005 (Trimodality) • Tepper et al – 2008 (Trimodality)

Phase III Trial Chir ± Preop RTCT

Phase III Trial Chir ± Preop RTCT

Phase III Trial Chir + Preop CT ± RT Phase III Trial Chir ± Preop RTCT

Phase III Trial Chir ± Preop RTCT

 Definitive Chemoradiation  Salvage Esophagectomy • RTOG 85-01 - 1999

Phase III Trial RT vs RTCT

• INT 0123 - 2002

Phase III Trial RTCT (50Gy) vs RTCT (65Gy)

 Chemoradiation  or Selective Esophagectomy

• FFCD 9102 - 2015 • ESSEN Trial - 2005

Phase II Trial RTCT ± Selective Chir

Phase III Trial RTCT in > PR RTCT vs Selective Chir