SPDS EXPERT REVIEW PANEL

F. Based on the supporting information, what are the cons/weaknesses of the method?

Only the ratios of the individual/total flavokavains and kavalactones are presented. The amount of total kavalactones is estimated based on a previous HPLC analysis - they were not individually determined.

G. Any general comments about the method?

The method could be a very useful screening method in quality control to predict the safety of kava.

Recommendation for the Method

Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

No. The submitted method could be a starting point for the identification and quantitation of flavokavains, but in the recent form it is lacking method performance data and does not address the analysis of dietary ingredients and dietary supplements.