SPDS EXPERT REVIEW PANEL

A. Does the applicability of the method support the applicability of the SMPR? If not, please explain what is missing. B. Does the analytical technique(s) used in the method meet the SMPR? If not, please specify how it differs from what is stated in the SMPR. C. Are the definitions specified in the SMPR used and applied appropriately in the method? If no, please indicate how the terms are used. D. Does the method, as written, contain all appropriate precautions and warnings related to the method's reagents, components, instrumentation, or method steps that may be hazardous? If no, please suggest wording or option(s). A. Are the definitions specified in the SMPR used and applied appropriately in the supporting documentation (manuscripts, method studies, etc...)? If not, please explain the differences and if the method is impacted by the difference. B. Is there information demonstrating that the method meets the SMPR Method Performance Requirements using the Reference Materials stated in the SMPR? If not, then specify what is missing and how this impacts demonstration of performance of the method.

Six ginsenosides specified in the Applicability statement are adequately addressed, as is their determination in Panax ginseng and P. quinquefolius. Pseudoginsenoside (F11) and notoginsenoside R1, indicated as optional, have not been covered; P. notoginseng, indicated as an optional analyte, was not evaluated.

Yes

Yes

Sure does

III. Review of Information in Support of the Method

Analytical terminology beyond reproach

Yes