SPDS EXPERT REVIEW PANEL

F. Based on the supporting information, what are the cons/weaknesses of the method?

I don't see any weakness other that the lack of blank check and control samples.

G. Any general comments about the method?

1. Any indication as to the stability of the 1000 ug/ml standard stock solutions kept at -20C

2. Are the reference standard solutions to be prepared from stock on the day of analysis and then discarded?

3. Curious as to why the tincture samples have an unusually high % RSD. Would have expected this matrix to have the lowest % RSD.

4. Slight typo in the heading of Table 5. Concentration of u/ml instead of ug/ml.

5. What became of the SMPR 2017.015?

Recommendation for the Method

Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

Yes. Solid method that meets the SMPR requirements.

This method uses equipment that is readily available in analytical laboratories and reduces the traditional analysis times from over an hour to only 15 minutes. It covers a wide range of matrices and component levels typically encountered in the marketplace.