SPDS EXPERT REVIEW PANEL

B. Does the analytical technique(s) used in the method meet the SMPR? If not, please specify how it differs from what is stated in the SMPR. C. Are the definitions specified in the SMPR used and applied appropriately in the method? If no, please indicate how the terms are used. D. Does the method, as written, contain all appropriate precautions and warnings related to the method's reagents, components, instrumentation, or method steps that may be hazardous? If no, please suggest wording or option(s). A. Are the definitions specified in the SMPR used and applied appropriately in the supporting documentation (manuscripts, method studies, etc...)? If not, please explain the differences and if the method is impacted by the difference. B. Is there information demonstrating that the method meets the SMPR Method Performance Requirements using the Reference Materials stated in the SMPR? If not, then specify what is missing and how this impacts demonstration of performance of the method.

There is limited information in sample preparation; only information for extract material and it is unknown if the other matrices of interest will be prepared similarly and the dilution amount is not specified. It is thus difficult to determine if this method meets the SMPR levels for analytical range and limits of quantification stated in mg/g for the samples.

yes

The preparation of the 0.1% formic acid solution (which states using phosphoric acid) specifies sequentially adding acid and water which can imply that the acid is added first and the water is added to it which is a hazard.

III. Review of Information in Support of the Method

Yes

No. None of the SMPR reference materials were evaluated with this method. No samples equivalent to the reference materials listed in the SMPR were evaluated with this method. The performance of this method in the analysis of samples other than the standard solutions cannot be accessed.