SPDS EXPERT REVIEW PANEL

F. Based on the supporting information, what are the cons/weaknesses of the method?

Performance of method in matrices other than standard solutions is unknown.

G. Any general comments about the method?

Method has not been written as per AOAC OMA guidelines. Chromatography does not appear ideal; there does not appear to be baseline separation. At 41 minutes the method has a long run-time.

Recommendation for the Method

Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

No. There is insufficient validation data to assess method performance. At this stage this method has only been developed and shown to be applicable in analysis of mixed standard solutions. Chromatography also does not appear ideal as figures 5 and 6 shows several peaks that do not appear to have baseline separation.