PracticeUpdate: Haematology & Oncology | Vol 1.No.3 - 2016

Anticoagulation therapy is not enough 1

• Recent registry data show that 46% of PNH patients receiving either prophylactic or therapeutic anticoagulation therapy experienced a thromboembolism. 1 • 31.3% of patients receiving prophylactic anticoagulant therapy experienced a first thrombosis. 1 • 57.1% of patients receiving therapeutic anticoagulant therapy experienced subsequent thrombotic events. 1 • Anticoagulant therapy does not address the complement-mediated haemolysis that leads to systemic complications in PNH. 2,3 To find out more phone 1800 788 189 or visit knowingpnh.com.au IN PNH, BOTH PROPHYLACTIC AND THERAPEUTIC ANTICOAGULANT THERAPY IS INSUFFICIENT TO PREVENT THROMBOEMBOLISM (TE) 1

References: 1. Lee JW, et al. Int J Hematol 2013;97:749-757. 2. Brodsky RA. Blood Rev. 2008;22:65-74. 3. Hill A, Kelly RJ, Hillmen P. Blood 2013;121:4985-4996. © 2016 Alexion Pharmaceuticals Australasia Pty Limited. All rights reserved. Alexion Pharmaceuticals Australasia Pty Limited. ACN 132 343 036. Suite 401, Level 4, Building A, 20 Rodborough Rd, Frenchs Forest. NSW 2086 Australia. September 2016. AU/DPNH/15/0007

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