Textbook of Medical-Surgical Nursing 3e
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Chapter 11
Oncology: Nursing management in cancer care
Table 11-2 Characteristics of Benign and Malignant Neoplasms Characteristics Benign Malignant Cell characteristics Well-differentiated cells that resemble normal
Cells are undifferentiated and often bear little resemblance to the normal cells of the tissue from which they arose Grows at the periphery and sends out processes that infiltrate and destroy the surrounding tissues Rate of growth is variable and depends on level of differentiation; the more anaplastic the tumour, the faster its growth Gains access to the blood and lymphatic channels and metastasises to other areas of the body Often causes generalised effects, such as anaemia, Often causes extensive tissue damage as the tumour outgrows its blood supply or encroaches on blood flow to the area; may also produce substances that cause cell damage Usually causes death unless growth can be controlled weakness and weight loss
cells of the tissue from which the tumour originated
Mode of growth
Tumour grows by expansion and does not infiltrate the surrounding tissues; usually encapsulated
Rate of growth
Rate of growth is usually slow
Metastasis
Does not spread by metastasis
General effects
Is usually a localised phenomenon that does not cause generalised effects unless its location interferes
with vital functions
Tissue destruction
Does not usually cause tissue damage unless its location
interferes with blood flow
Ability to cause death
Does not usually cause death unless its location interferes
with vital functions Reproduced with permission from Porth, C. M. & Matfin, G. (2009). Pathophysiology: Concepts of altered health states (8th ed.). Philadelphia: Lippincott Williams & Wilkins.
Typically, nuclei of cancer cells are large and irregu- larly shaped (pleomorphism). Nucleoli, structures within the nucleus that house ribonucleic acid (RNA), are larger and more numerous in malignant cells, perhaps because of increased RNA synthesis. Chromosomal abnormalities (trans- locations, deletions, additions) and fragility of chromosomes are commonly found when cancer cells are analysed. Mitosis (cell division) occurs more frequently in malignant cells than in normal cells. As the cells grow and divide, more glucose and oxygen are needed. If glucose and oxygen are unavailable, malignant cells use anaerobic metabolic channels to produce energy, which makes the cells less dependent on the Malignant disease processes have the ability to allow the spread or transfer of cancerous cells from one organ or body part to another by invasion and metastasis. Patterns of meta stasis can be partially explained by circulatory patterns and by specific affinity for certain malignant cells to bind to molecules in specific body tissue. Invasion, which refers to the growth of the primary tumour into the surrounding host tissues, occurs in several ways. Mechanical pressure exerted by rapidly proliferating neo- plasms may force finger-like projections of tumour cells into surrounding tissue and interstitial spaces. Malignant cells are less adherent and may break off from the primary tumour and invade adjacent structures. Malignant cells are thought to possess or produce specific destructive enzymes (proteinases) such as collagenases (specific to collagen), plasminogen acti- vators (specific to plasma) and lysosomal hydrolyses. These enzymes are thought to destroy surrounding tissue, including the structural tissues of the vascular basement membrane, facil- itating invasion of malignant cells. The mechanical pressure of a rapidly growing tumour may enhance this process. Metastasis is the dissemination or spread of malignant cells from the primary tumour to distant sites by direct spread of tumour cells to body cavities or through lymphatic and blood circulation. Tumours growing in or penetrating body cavities may shed cells or emboli that travel within the body cavity and seed the surfaces of other organs. An example of this process availability of a constant oxygen supply. Invasion and metastasis
can occur in ovarian cancer when malignant cells enter the peritoneal cavity and seed the peritoneal surfaces of such abdominal organs as the liver or pancreas. Lymphatic and haematogenous spread Lymph and blood are key mechanisms by which cancer cells spread. Angiogenesis, a mechanism by which the tumour cells are ensured a blood supply, is another important process. The most common mechanism of metastasis is lym- phatic spread, which is transport of tumour cells through the lymphatic circulation. Tumour emboli enter the lymph channels by way of the interstitial fluid that communicates with lymphatic fluid. Malignant cells may also penetrate lymphatic vessels by invasion. After entering the lymphatic circulation, malignant cells either lodge in the lymph nodes or pass between lymphatic and venous circulation. Tumours arising in areas of the body with rapid and extensive lym- phatic circulation are at high risk for metastasis through lymphatic channels. Breast tumours frequently metastasise in this manner through axillary, clavicular and thoracic lymph channels. Another metastatic mechanism is haematogenous spread, by which malignant cells are disseminated through the blood- stream. Haematogenous spread is directly related to the vas- cularity of the tumour. Few malignant cells can survive the turbulence of arterial circulation, insufficient oxygenation or destruction by the body’s immune system. In addition, the structure of most arteries and arterioles is far too secure to permit malignant invasion. Those malignant cells that do survive this hostile environment are able to attach to endothelium and attract fibrin, platelets and clotting factors to seal themselves from immune system surveillance. The endothelium retracts, allowing the malignant cells to enter the basement membrane and secrete lysosomal enzymes. These enzymes then destroy surrounding body tissues and thereby allow implantation. Angiogenesis Angiogenesis is the growth of new capillaries from the host tissue by the release of growth factors and enzymes such as vascular endothelial growth factor (VEGF). These proteins
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