Statistics Meeting Book (June 20, 2018)

Progress updates a. Statistics for Microbiology Methods Validation - Paul Wehling & Robert LaBudde (Leads) 1. Progress for Internal Validation Plan a. Robert LaBudde b. Paul Wehling

Volunteers: 1. Qian Graves 2. JaneWeitzel

b. Changes to Appendix J (in progress) - Paul Wehling & Robert LaBudde (Leads) 1. Quantitative methods need changes (performed during &/or after validation) a. Candidate minus Reference b. New method of calculating the CI for the paired dPod c. Use of Z (n) vs. t (n-1) d. Removal of reference to Welch/Satterthwaite t-test?

e. Chi-Square Test Calculator (Robert/Paul) http://lcfltd.com/AOAC/aoac‐binary‐v2‐5.xlsx i. To be discussed with Appendix J changes

(Paul and Robert have been working on this Shared 2 files related to the project (see Delia’s email on 5/23): ANNEX A MPN Analysis of Contaminated Matrix and AOAC annual meeting slides: Improved confidence interval for difference in POD for two

methods in a paired qualitative study Members should review the 2 files Paul: Still need more work, need more equations)

c. Statistics Committee’s Terms of Reference (ToR) Update – All, ToR Subcommittee 1. Latest version – v8 has been approved by OMB

a. Sent to Committee on Statistics b. Board of Directors to vote in June

We are waiting for Board of Directors’ approval

*Requires a vote

version 1

Draft meeting agenda is subject to change without notice

d. Bimonthly article to be published in every issue of ILM, called “Random Thoughts”, of Statistical interest, by the Stat Committee Members on a Voluntary Basis: a. Next Article to be published in the July/August 2018 Issue by Robert LaBudde b. “The 4 faces of botanical identification in dietary supplements” 1. From R. Rathbone, Editor, ILM “A typical article may run 500‐600 words, with graphics/pictures, etc. This would be a page.” 2. Title: ‘Random Thoughts’ 3. Request for Volunteers for short articles: a. Equivalency Testing by Robert LaBudde - Done! b. Measurement Uncertainty or related, by Jane Weitzel c. Ideas for future issues: Topics of Interest for AOAC Analytical Community i. Intermediate Precision ii. False Positive/False Negative & its relationship to the POD Model iii. LOD/LOQ iv. Proficiency Testing