SPDS Set 1 ERP Book
PDE5-005
they are linear from 50 to 1000 ppm in the sample. The consumables are inexpensive. The cost of the DART itself, compared with other DART instruments on the market, is reasonable. It would still need a highly skilled operator for the instrument. The method is very clear and easy to follow. All the parameters necessary for operation of the mass spectrometer are included in the method and easy to use. small sample size, easy extraction, ease of automation, use of MS/MS for selectivity and sensitivity, very low LOD, ability to do triggered MRM's. The data is easy and straight forward. The experimental conditions are outlined and straight forward. It uses internal standards to help with the Quantitation. The method is very specific and very selective. The optimization is very clear and straight forward. It has been optimized for the compounds of interest molecular mass. Performance Characteristics 50 - 1000 ppm in the sample, meets requirements of SMPR 2014.011 Needs the use of a highly skilled operator. Supporting Data
Method Clarity
Pros/Strengths
Cons/Weaknesses
General Comments
Method Optimization
Analytical Range:
LOQ:
50 mg/kg meets 2014.011
Average of 83.2 for all 15 compounds. Meets SMPR requirements of 2014.011
Accuracy/Recovery
Precision (RSDr)
Overall, precision meets SMPR 2014.011
Reproducibility (RSDR)
Overall, reproducibility meets SMPR 2014.011
System Suitability
Safety Review
Is the method safe to use as written? Yes Are there any safety concerns with any component, instrument, reagent or instruction of the method? If yes, please clearly state the concerns.
Yes, safety statement is there in the method.
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