2018 Section 6 - Laryngology, Voice Disorders, and Bronchoesophalogy

AE Vertigan et al .

P -value Hypothesis 1, versus controls † P -value Hypothesis 2, versus cases ‡

% ACE inhibitor 12.1 17.9 0 5.6 7.6 0.581 0.050 % asthma 18.2 42.9# 27.3 38.9# 0 < 0.001 0.006 Reflux Symptom Index Score 20.8 (9.8) 23.8 (11.2) 23.1 (10.5) 17.2 (6.7) 1.6 (1.2) < 0.001 0.153 Anxiety 6.3 (4.6) 6.9 (4.4) 8.8 (5.5) 4.6 (3.5) 3.0 (2.4) 0.013 0.093 Depression 4.8 (4.1) 4.0 (3.4) 2.9 (2.7) 3.5 (3.5) 1.3 (1.2) 0.040 0.449 FEV 1 % predicted 94.5 (16.1) 87.8 (15.2) 91.1 (14.0) 93.4 (18.8) 104.5 (16.1) 0.047 0.155 FVC % predicted 93.5 (12.6) 90.3 (13.2) 92.4 (15.2) 95.8 (15.3) 106.8 (15.3) 0.021 0.692 All patients had been medically managed for all associated conditions. * P < .008 versus MTD; P < 0.008 versus PVFM; # P < .008 vs CRC. Values are mean (SD) unless otherwise stated. † P -values for analysis of all groups vs controls; ‡ P -values for analysis of case groups. ACE, angiotensin converting enzyme; CRC, chronic refractory cough; FEV1, forced expiratory flow in one second; FVC, forced vital capacity; MTD, functional dysphonia; PVFM, paradoxical vocal fold movement; VAS, visual analogue scale. Upper airway-laryngeal Co-morbidity index 1.4 (0.9) 1.9 (1.0) 1.2 (1.0) 1.4 (1.2) 0.0 (0.0) < 0.001 0.116

Primary presenting symptom Cough Difficulty breathing Lump in throat Dysphonia N/A Presenting symptom severity (VAS) cm 4.9 (2.4) 5.3 (2.3) 5.6 (2.9) 5.5 (2.5) N/A N/A 0.761 Age (years: M (SD)) 58.7 (14.9) 54.8 (12.1) 53.45 (12.8) 51.2 (18.8) 52.1 (12.7) 0.378 0.341 Age (years: range) 20–82 22–78 26–66 22–80 30–66 % female 81.8 78.6 72.7 77.8 69.2 0.884 0.716 Duration symptom (months) 86.2 (111.3) 70.3 (106.8) 53 (75.5) 27.7 (37.4) N/A N/A 0.210 % reflux 69.7 71.4 63.6 50 0 < 0.001 0.221 % rhinitis 36.4 57.1 27.3* 61.1 0 < 0.001 < 0.001

n = 13

Healthy controls

MTD n = 18

Globus n = 11

PVFM n = 28

n = 33

CRC

Table 3 Participant details

Diagnostic group

Respirology (2013) 18 , 948–956

© 2013 The Authors Respirology © 2013 Asian Pacific Society of Respirology

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