2018 Section 6 - Laryngology, Voice Disorders, and Bronchoesophalogy

S. E. Attwood et al.

Table 1 | Laboratory variables (median values) in patients treated with anti-re fl ux surgery (ARS) or a proton pump inhibitor (PPI) in the SOPRAN and LOTUS studies. Patients received open ARS or omeprazole in the SOPRAN study and laparoscopic ARS or esomeprazole in the LOTUS study

SOPRAN

LOTUS

Laboratory variable (treatment group) Haemoglobin (g/dL) ARS group

Baseline 1 year 3 years 5 years

Baseline 1 year 3 years 5 years

N

N

90 – 105 13.9 92 – 107 14.0

13.7 13.6 13.8 14.1

13.2 160 – 241

15.0

14.8 15.1

15.0

PPI group

13.4 186 – 264 15.1

15.1

15.2

15.1

Vitamin B 12

(pmol/L)

ARS group PPI group

110 – 132 333 123 – 143 330

309 321 323 332

308

157 – 245 309 180 – 265 304

297 298 320 320

289 317

321

Gastrin (pmol/L) ARS group

101 – 123 19

14 29

15

10 31

157 – 245 25 180 – 265 24

23 54

23 55

24 62

PPI group

117 – 131

18

36

Chromogranin A (ng/mL) ARS group

N/A N/A N/A N/A N/A 157 – 245 57.9

38.0 34.7 40.6

PPI group

N/A N/A N/A N/A N/A 180 – 265 57.6 123.4 147.4 145.8

Ferritin ( l g/L) ARS group

84 – 103 92

66

55 67

80 79

158 – 245 111 180 – 265 118

109 120

122 156

PPI group

93 – 111

70

71

131

133

Iron ( l mol/L) ARS group

N/A N/A N/A N/A N/A 158 – 245 19.2 N/A N/A N/A N/A N/A 180 – 265 18.3

20.4 19.0 19.2

PPI group

19.0 17.9

17.9

Iron-binding capacity ( l mol/L) ARS group

N/A N/A N/A N/A N/A 158 – 245 55.0 55.7 53.5

56.7

PPI group

N/A N/A N/A N/A N/A 179 – 265 53.9

54.4 53.0 55.1

Homocysteine ( l mol/L) ARS group

N/A N/A N/A N/A N/A 157 – 245 10.6 N/A N/A N/A N/A N/A 180 – 265 10.7

10.8 10.3

11.8 11.7

PPI group

11.1

10.7

Folate*

ARS group PPI group

35 – 59 498 40 – 63 555

472 492 529 548

373

N/P

N/P N/P

N/P N/P N/P N/P

N/P N/P

540 N/P

Zinc ( l mol/L) ARS group

N/A N/A N/A N/A N/A 156 – 243 13.6 N/A N/A N/A N/A N/A 175 – 264 13.7

13.2 12.4 13.4 12.2

11.9

PPI group

12.1

ALP (U/L)

ARS group PPI group

73 – 79 177 78 – 95 181

166 168 179 180

159 176

151 – 244 70 184 – 265 69

67

69

66 65

70 70

ALT (U/L)

ARS group PPI group

65 – 71

31

24 32

26 32

30 29

159 – 245 29 186 – 265 28

23 28

24 28

23 29

65 – 82 35

AST (U/L)

ARS group PPI group

60 – 70 24 69 – 87 26

22 25

23 25

25 24

159 – 245 22 186 – 265 22

21 23

21 23

21 23

Calcium (mmol/L) ARS group

102 – 134 2.4 119 – 146 2.3

2.3 2.3

2.4 2.3

2.3 151 – 243 2.3 183 – 265

2.3 2.4

2.3

2.3

2.3 2.3

PPI group

2.4 2.3

Vitamin D (nmol/L) ARS group

N/A N/A N/A N/A N/A 157 – 245 45 N/A N/A N/A N/A N/A 180 – 265 46 49 ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; N/A, not assessed; N/P, not presented. *Folate data from the LOTUS study had a similar pattern to that from the SOPRAN study but are not presented owing to issues regarding the compatibility of the data. 58 59 52 56 48 PPI group

Aliment Pharmacol Ther 2015; 41: 1162 – 1174 ª 2015 John Wiley & Sons Ltd

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