SPADA Working Groups ~ April Meeting Book
A A Q Fever Pneumonia: Guinea pig model PBS Cont rol 1 2 3 A
B 2
B 3
B 1
7 da ys p.i. 28 day
C 1
C 2
C 3
s p.i. 28 days p.i., vaccina ted
D 1
D 2
D 3
C. burnetii infection leads to pneumonia at high doses. 7d pi – panleukocytic bronchointerstitial pneumonia 28d pi – lymphohistiocytic interstitial pneumonia
Formalin inactivated Whole Cell Vaccine (WCV) Q-vax ® : Effective Q fever vaccine licensed for used in Australia Long-lived, single dose Not FDA approved: IND material Serious side effects in previously sensitized individuals (local and systemic) Requires pre-screening: Skin test and phase I/phase II serology
Next generation vaccines under development
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