SPADA Working Groups ~ April Meeting Book
Aerosol exposure • Based upon accidental laboratory inhalation exposure • Symptoms noted within 90 minutes‐24 hours after exposure • Symptomatic 3‐4 days – Fever – Headache – Muscle aches – Pulmonary symptoms – GI symptoms
Superantigenic properties of SEs • Cross link T‐cells with Antigen Presenting Cells • By‐passing antigen processing • Activates large populations of T‐cells • Release of cytokines T i h k d t • ox c s oc syn rome symp oms • Fever, hypotension vomiting, diarrhea, rash, renal failure • Associated with SEA, SEB, and SEC
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