Practice Update: Cardiology


VOL. 1 • No. 1 • 2016 ISSN 2206-4672


Tissue factor and inflammatory cytokines may play a role in chronic thromboembolic pulmonary hypertension


Practice trumps theory, and pursuit of “hard” clinical endpoints should and must remain the bedrock of informing our interventions to manage patients’ cardiovascularrisk Dr Peter Libby 4

MYOCARDIALDISEASE Global LGE on CMR is a helpful prognostic indicator in patients with AL cardiac amyloidosis. 5 CORONARYHEART DISEASE “This is an exciting period for imaging in cardiovascular disease, and T1 mapping continues to generate much enthusiasm as a developing technique with the potential for having substantial clinical impact on diagnosis and management strategies. 6 CONFERENCE CHEST A gas-driven pump is used to deliver prostacycline in patients with severe PHTN 10 Long-term mechanical ventilation is e ective in children with PHTN Balloon pulmonary angioplasty reduces mean pulmonary arterial pressure to ≤30 mmHg INTERVENTIONAL CARDIOLOGY Not only does guideline-based therapy for acute myocardial infarction improve 30-day survival, it also results in a sustained benefit in survival that can be observed as far out as 17 years. 15 11 12

Tissue factor gene expression has been shown to be increased in patients with chronic thromboembolic pulmonary hypertension. 3

More stories from CHEST 2016 inside! See page 10.

Increased incidence of ventricular arrhythmias in patients with advanced cancer and ICDs JACC Clin Electrophysiol One-third of patients who had received ICDs developed ventricular arrhythmia after a diagnosis of cancer.

Pulmonary artery pressure-guided heart failure management reduces 30-day readmissions Circ Heart Fail Pulmonary artery pressure-guided HF management in US Medicare-eligible patients led to a 49% reduction in total HF hospitalisations and a 58% reduction in all-cause 30-day readmissions.

Rare mutation in ASGR1 is associated with a reduced risk of CAD N Engl J Med Less is more when it comes to the activity of the asialoglycoprotein receptor (ASGR1). ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease. 6

Novel method for earlier detection of phrenic nerve injury during cryoballoon ablation Heart Rhythm Recovery from PNP improved from months to hours post-operatively by utilising an improved method

The incidence was significantly higher in those with advanced metastatic disease.

of pacing with the minimum output.




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