PracticeUpdate Neurology June 2019

CONTENTS 5

RESEARCH Editor’s picks 7 Brain State-Dependent Stimulation Boosts Functional Recovery Following Stroke

COVER 9

Validated Outcome of Treatment Changes According to International League Against Epilepsy Criteria in Adults With Drug-Resistant Focal Epilepsy Comment by Sara Inati MD

8 Neural Basis of Induced Phantom Limb Pain Relief 8 Clinical Spectrum of Neuromuscular Complications After Immune Checkpoint Inhibition 9 Validated Outcome of Treatment Changes According to International League Against Epilepsy Criteria in Adults With Drug-Resistant Focal Epilepsy Comment by Sara Inati MD 10 Clinical Features of Sleep-Related Hypermotor Epilepsy in Relation to the Seizure-Onset Zone 11 Evidence-Based Management of Pediatric Myotonic Dystrophy Type 1 11 Outbreaks of Acute Flaccid Myelitis? What Neurologists Need to Know

CONFERENCE 18 International Stroke Conference 2019 By the PracticeUpdate Editorial Team

12 Subthalamic Stimulation, Apomorphine, and Levodopa Infusion Have Distinct Effect Profiles in Parkinson’s Disease 13 Treatment Approach to NREM Parasomnias 13 Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy 14 Atypical CIDP: Diagnostic Criteria, Progression, and Treatment Response 14 MRI or CT Before Treatment in Acute Ischemic Stroke 15 Risk and Predictors of Dementia and Parkinsonism in Idiopathic REM Sleep Behavior Disorder 16 Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis Comment by Erin Longbrake MD, PhD 17 Restoration of Brain Circulation and Cellular Functions Hours Post Mortem

18 Target: Stroke Phase II Improves Door-to-Needle Times in Acute Ischemic Stroke 19 Late Thrombectomy for Stroke Linked With Better Quality of Life Outcomes in DEFUSE 3 19 Some Stroke Patients May Benefit From Thrombolysis Beyond Standard 4.5-Hour Time Window 20 130/80 mmHg Identified as Likely Best Target for Repeat Stroke Prevention 21 SCENT Trial Reveals High Success Rates With Surpass Flow Diverter in Challenging Aneurysms 22 Minimally Invasive Surgery May be Option for Intracranial Hemorrhage

VOL. 4 • NO. 2 • 2019