Biophysical Society 61st Annual Meeting | Program Guide

2671-Pos Board B278 MOLECULAR CLONING AND EXPRESSION OF CDNA ENCODING THE RYANODINE RECEPTOR TYPE 2 FROM RATTUS NORVEGICUS CEREBRAL ARTERY SMOOTH MUSCLE. Jianxi Liu, Guruprasad Kuntamallappanavar, Venkatasushma Kalava, Alex Dopico 2672-Pos Board B279 MCU AND EMRE BINDING IS MEDIATED THROUGH INTERMEMBRANE HELIX-HELIX INTERACTIONS. Charles Phillips Voltage-gated K Channels and Mechanisms of Voltage Sensing and Gating IV (Boards B280–B288) 2673-Pos Board B280 STATE-DEPENDENT STRUCTURAL MODELING AND ATOMISTIC SIMULA- TIONS OF THE HERG POTASSIUM CHANNEL. Kevin R. DeMarco, Phuong T. Nguyen, Toby W. Allen, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Igor Board B281 EFFECT OF MEMBRANE COMPOSITION ON ION CONDUCTION IN A VOLT- AGE-GATED POTASSIUM CHANNEL. Niklaus B. Johner , Simon Berneche 2675-Pos Board B282 K + OCCUPANCY IN THE CAVITY DETERMINES THE ION PERMEATION RATE THROUGH THE KV1.2 CHANNEL. Takashi Sumikama , Shigetoshi Oiki 2676-Pos Board B283 ON RESOLUTION OF THE SELECTIVITY/CONDUCTIVITY PARADOX FOR THE POTASSIUM ION CHANNEL. Dmitry G. Luchinsky , Will A.T. Gibby, Igor Kh Kaufman, Dogan A. Timucin, Peter V.E. McClintock 2677-Pos Board B284 WEIGHTED ENSEMBLE APPROACH TO IN SILICO MEASURE THE I-V RELA- TIONSHIP IN A K + ION CHANNEL. Sara Capponi , Joshua Adelman, John Rosenberg, Michael Grabe 2678-Pos Board B285 QUANTUM CALCULATIONS OF LARGE SEGMENTS OF A VOLTAGE SENSING DOMAIN OF A VOLTAGE GATED CHANNEL. Alisher M. Kariev , Michael E. Green 2679-Pos Board B286 QUANTUM CALCULATIONS OF SALT BRIDGES, THEIR IONIZATION STATE IN THE INTERIOR OF VOLTAGE SENSING DOMAINS OF VOLTAGE GATED CHANNELS, AND SOME CONSEQUENCES. Alisher M. Kariev, Michael E. Green 2680-Pos Board B287 TRUE OR FALSE? “THE ARGININES AND LYSINES OF THE S4 SEGMENT OF A VOLTAGE-SENSITIVE ION CHANNEL REPEL ONE ANOTHER ELECTRO- STATICALLY”. H. Richard Leuchtag 2681-Pos Board B288 FINDINGS FROM CONDENSED-STATE PHYSICS ON BRANCHED-CHAIN AMINO ACIDS APPLY TO VOLTAGE-SENSITIVE ION CHANNELS. H. Richard Leuchtag Ion Channel Regulatory Mechanisms II (Boards B289–B296) 2682-Pos Board B289 TRANSPORT OF WATER AND IONS THROUGH A GRAPHENE NANOPORE IN AN ELECTRIC FIELD. Anping Ji , Zhongwu Li, Haojie Yang, Pinyao He, Yunfei Chen Vorobyov 2674-Pos

2659-Pos Board B266 INORGANIC POLYPHOSPHATE PROTECTS NEURONS AGAINST GLUTA- MATE-INDUCED EXCITOTOXICITY. Marta Maiolino, Vincenzo Lariccia, Salvatore Amoroso, Plamena R. Angelova, Andrey Y. Abramov Intercellular Calcium Channels and Calcium Sparks and Waves II (Boards B267–B279) 2660-Pos Board B267 ATP RELEASE THROUGH GAP JUNCTION HEMICHANNELS INCREASES CA 2+ SPARK OCCURRENCE VIA P2Y PURINOCEPTOR SIGNALING IN RAT VENTRICULAR MYOCYTES UNDER SHEAR STRESS.  Jun Wang , Joon-Chul Kim, Sun-Hee Woo 2661-Pos Board B268 STRUCTURAL DYNAMICS OF CALMODULIN IN REGULATION OF CALCIUM RELEASE IN HEALTH AND DISEASE. Megan R. McCarthy , Robyn T. Rebeck, Razvan L. Cornea, David D. Thomas 2662-Pos Board B269 EFFECTS OF EXPRESSION LEVELS OF WT AND MUTANT RYR2 ON CA 2+ HOMEOSTASIS IN HEK CELLS. Nagomi Kurebayashi , Takashi Murayama, Naoyuki Tetsuo, Ryosaku Ohta, Fumiyoshi Yamashita, Takashi Sakurai 2663-Pos Board B270 EFFECTIVE SUPPRESSION OF ARRHYTHMOGENIC CA WAVES BY FLE- CAINIDE IN VENTRICULAR MYOCYTES FROM CASQ2 -/- MICE DEPENDS ON CAMKII ACTIVITY. Dmytro Kryshtal , Nieves Gomez-Hurtado, Bjorn Knollmann 2664-Pos Board B271 CARDIAC SPECIFIC IP 3 R OVER-EXPRESSION: IP3ICR CONTRIBUTION IN CA 2+ SIGNALING.  Joaquim Blanch i Salvador , Marcel Wullschleger, Marcel Egger 2665-Pos Board B272 DYNAMICAL INTERACTIONS OF EARLY AFTERDEPOLARIZATIONS WITH STRETCH ACTIVATED CHANNELS. Dexter K. Luu , Daisuke Sato, Yuanfang Xie 2666-Pos Board B273 MODELLING CALCIUM-INDUCED-CALCIUM-RELEASE FROMMEASURE- MENTS OF RYR GATING. Derek R. Laver , Cherrie H. Kong, Mark B. Cannell 2667-Pos Board B274 MODULATION OF CA 2+ SIGNALING IN HL-1 CARDIOMYOCYTES BY AR- RHYTHMOGENIC RYR2 MUTANTS. Naoyuki Tetsuo , Nagomi Kurebayashi, Takashi Murayama, Takashi Sakurai 2668-Pos Board B275 HOW DOES CALCIUM OVERLOAD GENERATE CALCIUMWAVES IN HEART? George S. B. Williams , Andrew P. Wescott, Stephan E. Lehnart, W. J. Lederer 2669-Pos Board B276 MECHANISM OF SINOATRIAL NODE DYSFUNCTION IN A RYR2R420Q MOUSE MODEL OFCATECHOLAMINERGIC POLYMORPHIC VENTRICU- LAR TACHYCARDIA. Yue-Yi Wang , Pietro Mesirca, Elena Marqués-Sulé, Alexandra Zahradnikova Jr, Olivier Villejoubert, Pilar d’Ocon, Cristina Ruiz, Diana Domingo, Esther Zorio, Matteo E. Mangoni, Jean-Pierre Benitah, Ana Maria Gomez 2670-Pos Board B277 ABLATION OF THE RYR2-SER2030 PHOSPHORYLATION SITE LIMITS CHANGES IN RYR2 SENSITIVITY DURING ß-ADRENERGIC STIMULA- TION. Duilio M. Potenza , Radoslav Janicek, Miguel Fernandez-Tenorio, Hector H. Valdivia, Ernst Niggli

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