AOAC SPDS Mid Year 2016

Background

Challenges • Clinical Phase I studies have shown that the blood serum  levels of curcumin are in the ng/mL range after oral doses  of up to 8 g of curcumin, suggesting very low gastro‐ intestinal bioavailability • The reasons for the low oral bioavailability of curcumin are  not yet known h i l i bili (d d i d ili f li id – c em ca nsta ty egra at on pro ucts are van n, eru c ac ,  feruroyl methane) 

– rapid metabolism – poor absorption – accumulation in cells of the gastro‐intestinal tract

Background

Analytical Needs • Quantitative method for curcuminoids in – Raw material (plant material without authentication) – Extracts

– Finished products containing only turmeric and/or curcuminoids – Finished products containing other ingredients (vitamins, other DS,  herbs)

• Quantitative method for curcuminoids in – Capsules  – Tablets – Tinctures – Softgel capsules