AOAC SPDS Mid Year 2016

Background

Existing Methods • SciFinder search: “turmeric and validation” and “2014‐2015”  yielded 97 references • Spectrophotometric method for  the estimation of curcumin  in bulk and pharmaceutical formulation • 1H‐NMR and PCR for detecting Curcuma longa wild species  adulterants • HPLC and LC/MS are widely used  analytical techniques

Workgroup meetings

Method Performance Requirements – High and low analytical range – Reproducibility (RSDR)  • Original: ≤2%  • Group discussion: ≤10% • After input from the industry members of the group:  ≤3 and ≤6% – Repeatability (RSDr) • Original: ≤1%   • Group discussion: ≤5% • After input from the industry members of the group:  ≤2 and ≤4%