2017 Imaging for Physicists Coursebook

Contrast Agents

Gadolinium agents better tolerated than iodinated (CT) agents Gd-DTPA (Magnevist) safety record: 5 million uses, 1,234 AEs (1992) Anaphylactic shock and death in 1 case

nephrogenic systemic fibrosis (NSF) in kidney dysfunction

Macrocyclic agents (Dotarem, Prohance, Gadovist) more commonly used IV EMA recently suspended linear agents (Magnevist, Optimark, Omniscan)