PracticeUpdate Diabetes Best of 2018

CONTENTS 5

CONFERENCE 20 American Diabetes Association 78th Scientific Sessions

TOP STORIES 2018 6 GLP-1 Receptor Agonists: HARMONY Outcomes and REWIND By Kathleen Dungan MD, MPH 7 Canagliflozin and Renal Outcomes in Type 2 Diabetes By Deborah Wexler MD, MSc 8 New ADA-EASD Type 2 Diabetes Treatment Guidelines By Silvio E. Inzucchi MD

20 Clinically Relevant Data on Pioglitazone and CV Risk Reduction Interview with Silvio E. Inzucchi MD 21 SGLT2 Inhibitors in the Management of Type 2 Diabetes Interview with John (Jack) L. Leahy MD by Jason Sloane MD 22 Sequencing Injectable Therapies in Type 2 Diabetes Interview with John (Jack) L. Leahy MD by Jason Sloane MD 22 Enteroendocrine Function of the Intestine By Jason Sloane MD 23 European Association for the Study of Diabetes 54th Annual Meeting By the PracticeUpdate Editorial Team

EXPERT OPINION 16 An Overview of New Diabetes Treatments Interview with John (Jack) L. Leahy MD by Jason Sloane MD 18 My Approach to Triglyceride Levels in EDITOR’S PICKS 10 Treatment in Type 1 and Type 2 Diabetes in Low-Resource Settings Comment by Sylvia Kehlenbrink MD and Meredith Hawkins MD, MS 11 12-Month Weight Loss Similar With Low-Fat and Low-Carbohydrate Diet Comment by Katherine Duffy MS, RD, CD-N, CDE 12 Differences in Gut Microbiota Composition and Functionality Among Children With Type 1 and MODY2 Comment by Li Wen MD, PhD 13 Semaglutide vs Dulaglutide Once Weekly in Patients With Type 2 Diabetes Comment by Kathleen Dungan MD, MPH

23 DISCOVER Study Finds High Complication Rate in Type 2 Diabetes 24 Very Tight Control in Gestational Diabetes Not More Beneficial 25 Consensus Guidelines for Managing Hyperglycemia in Type 2 Diabetes Released by American and European Diabetes Associations 26 Diuretics Linked With Greater Amputation Risk in Type 2 Diabetes 26 PIONEER Shows Safety and Efficacy of Oral Formulation GLP-1 Receptor Agonist

Specific Patient Scenarios Interview with Paul D. Thompson MD by Jennifer N. Caudle DO

VOL. 2 • NO. 4 • 2018