EBRO 2017

PCI in extensive SCLC

PCI N =143 15 % [8 – 21] 27 % [19 – 36]

Control N = 143 40 % [32 – 49] 13 % [8 – 20]

HR NTT p

Symptomatic brain mets

0.27 [0.16 – 0.44] 0.68 [0.59 – 0.88]

4 <0.0001

OS 1 yr

7 0.003

 Extensive SCLC, 18 - 75 yrs., WHO 0 – 2, 2001 – 2006

 Response to chemotherapy

 Radiotherapy within 4 – 6 weeks after chemotherapy

 20/8, 20/10, 24/12, 30/10, 30/12

Slotman NEJM 2007