EBRO 2017

The GRADE approach

GRADE

• GR ading of recommendations, A ssessment, D evelopment and E valuations Working Group • Systematic and explicit approach to preparing evidence- based systematic reviews and clinical guidelines

GRADE categorises the quality of the evidence

• Study limitations

Large magnitude of effect

• Inconsistency of results • Indirectness of evidence

Plausible biases would reduce effect

Dose-response gradient

• Imprecision • Publication bias

Guyatt British Medical Journal 2008

ESTRO: Evidence-based Radiation Oncology