EBRO 2017

Most influencial studies H&N cancer 2000-2006

Study

No. study- arms

No. patients

No. centers

Duration (years)

No. patients in experimental arm per center per year

Fu, Int J Rad Oncol Biol Phys 2000 fractionation

3,1

4

1113

45

6

Overgaard, Lancet 2003 fractionation

2

1476

6

8

15,4

Forastiere, N Engl J Med 2003 radiotherapy ± chemotherapy

< 0,5

3

547 > 100

8

Bernier, N Engl J Med 2004 surgery+ radiotherapy ± chemotherapy Cooper, N Engl J Med 2004 surgery+ radiotherapy ± chemotherapy

1,0

2

334

23

7

< 0,5

2

459 > 100

5

0,9

Bonner, N Engl J Med 2006 radiotherapy ± cetuximab

2

424

73

3