EBRO 2017

Multivariate analysis of CBC (Cox's model)

RR

IC 95%

p

Controls

1

< 10 -3

Non carriers

1.9

[1.1-3.2]

BRCA1/2 mutation carriers

5.2

[2.6-10.4]

On multivariate analysis the BRCA mutation status was the only significant predictor for the risk to develop contralateral cancer (p<10 -4 ). Age, lymph node status, hormonal receptor status, and tumour grade were not significant predictors of local recurrence.