EBRO 2017

More extreme whole breast hypofractionation?

Centre Antoine-Lacassagne A et al (2006) Radiother Oncol 79:156-161

Courdi

• 115 patients median age 83 • 32.5Gy in 5 x 6.5Gy once-weekly with 6.5Gy boost • Good local control, grade 3 fibrosis in 6% (95%CI 1.7-9.5)

• 50 patients ≥ 70 years old • 32.5Gy in 5 x 6.5Gy once-weekly, no boost • Compared to 317 patients treated 50Gy in 25# • Equivalent control, no toxicity data Institut Curie Breast Cancer Study Group et al (2009) Int J Radiat Oncol Biol Phys 75:76-81

Kirova Y

UK FAST Trial

Fast

Trialists Group (2011) Radiother Oncol 100:93-100

• Multicentre randomised trial 2004-2007, 915 patients • 50Gy 25 # vs. 28.5Gy 5 x 5.7Gy once weekly vs. 30Gy x 6Gy once weekly • First report at median follow-up 3 years