EBRO 2017

German Rectal Cancer Study CAO/ARO/AIO (1995-2002)

• Study group

– 823 patients – Clinical stage T3-4 or N+ (operable) – Inferior margin within 16 mm from anal verge

• Randomisation – Chemo-RT (50.4 Gy) + surgery (TME) + 4 x bolus 5-FU – Surgery (TME) + chemo-RT (55.8 Gy) + 4 x bolus 5-FU (Chemo-RT = 5-FU 1000 mg/m2/d D1-5, weeks 1+5)

Sauer R, N Engl J Med. 2004;351(17):1731-40