EBRO 2017

Case 1 Chemotherapy

• Multiple trials demonstrate benefit from adjuvant chemotherapy in HGG • First meta-analysis in 1993 • 16 trials; 3000 patients; 10% improvement in OS • 12 Trials; IPD MA; 3004 patients; Improved Median OS by 2 months • Phase 2 trial of RT + TMZ

Fine, Cancer 1993 Stewart, Lancet 2002 Athanassiou, JCO, 2005