EBRO 2017

Case 2

• NOA-8 study • 412 pts; GBM or G3 Astrocytoma; >65 yr old; Non-inferiority 25% margin • TMZ 100mg/m2 d1-7q14 or • RT 60 in 30

• Median OS 8/12 • 73/209 pts were MGMT-meth • MGMT-meth > MedianOS • MGMT-meth & TMZ > EFS • MGMT-non-meth & RT > EFS

MGMT-non-meth (12 vs 8 months)

MGMT-meth & RT

MGMT-non-meth & TMZ

Wick Lancet Onc 2012