Course book Advanced Treatment Planning 2018

Parameters for clinical outcome: Rectum

Multivariate modeling for detecting rectal toxicity (G3 late rectal bleeding)

Surgery+ TD

50 = 82,5 Gy < Surgery- TD 50

= 91,7 Gy

Isoeffective TD

50 is 11% lower for Surgery+

n

n :

0.046

TD

: 82.5 Gy

1

   

   

1

50

= 

n Dv

EUD



TD

: 93.1 Gy

NTCP

=

;

Logistic regression:

50

i

i

k

50 EUD TD

  

  

k :

10.4

TD

: 91.7 Gy

i

50

1

+

T Rancati et al. Inclusion of clinical risk factors into NTCP modeling of late rectal toxicity after high dose radiotherapy for prostate cancer. Radiother Oncol 100 (2011) 124–130.