Cervix BT - 2016

Clinical radiobiology All models are wrong, but some are useful (David R. Wigg)

LQ-model has proven to be a useful tool for radiobiological calculations in brachytherapy:  Fowler JF. Dose reduction factors when increasing dose rate in LDR or MDR brachytherapy of carcinoma of the cervix. Radiother Oncol 1997;45:49-54.  Dale RG et al. Calculation of integrated biological response in brachytherapy. Int J Radiat Oncol Biol Phys 1997;38:633-642.  Nag S, et al. A simple method of obtaining equivalent doses for use in HDR brachytherapy. Int J Radiat Oncol Biol Phys 2000;46:507-513.  Lang S, et al. Treatment planning for MRI assisted brachytherapy of gynecologic malignancies based on total dose constraints. Int J Radiat Oncol Biol Phys 2007;69:619-627  The effect of alternative biological modelling parameters (a/b and half time of repair T1/2) on reported EQD2 values in the treatment of advanced cervical cancer. De Leeuw 2011 Radiother Oncol Nov 101(2) 337-42  Determining DVH parameters for combined external beam and brachytherapy treatment: 3D biological dose adding for patients with cervical cancer Van de Kamer 2010, RaditherOncol 94;248-253 Despite all limitations and simplifications, the LQ-model can be used for treatment planning and reporting