Molecular Imaging 2017

Rationale for Using Amino Acids-PET/SPECT for Tumor Tissue Detection in Gliomas

• High uptake in tumor cells mediated by the L-/A-amino acid transport. • Amino acids not taken up by normal cortical gray matter. • Good target-to-background contrast, allowing better characterization and differentiation of tumor from normal cortical tissue. (Ishiwata 1993; Kanai 1998)

transformed BHK 21

wildtype BHK 21

Accumulation of alpha-amino- isobutyrat (AIB) in-vitro