Brain 17 Vienna

Studies on neuro-toxicity in gliomas

Author year

Setting Tumor Nr

Dose Resp.

Tumor PD Worsening of NC Significant improvement

Taylor

1998

Pro

HGG

701

60Gy

No significant Neurotoxicity Worsening at 1, 2, 5 years: 8.2, 4.6, 5.3%

Brown

2001

Pro

LGG

203

50.4 vs 64 Gy

59%, 50%, and 67% at years 1, 2, and 5,

Armstrong

2000

Pro

LGG

20

46-63 Gy Verbal decline at 3m, recovery at 1y

-

Vigliani

1996

Pro

LGG

17

54-55.8 Gy

No tox compared to matched pairs, improvement* No significant impairment

-

Klein

2001

Retro

LGG

195

n.r.

n.r.

Taphoorn

1994

Retro

LGG

41 (20 RT/21 Sg only)

45-63 Gy No difference Comparison to 19 haem dis. CHT,LGG both groups with lower Cog/mood/asteni a

-