AOAC ISPAM Stakeholder Panel Meeting Book (August 26, 2018)

Action Item #1-A

Problem: large bias coinciding with small s is accepted as being equivalent .

1.0

0.5

bias Ά-ETI lower Ά-ETI upper

0.0

0.00

1.00

2.00

3.00

4.00

5.00

6.00

AL AL

-0.5

ALs ALs

-1.0

Comparison

Small s for alternative and reference. Large bias. Current AP Æ accept when it shoudl reject (caused by large value of AL)

y = 0.9894x + 0.3849

0.0 1.0 2.0 3.0 4.0 5.0 6.0

Alternative

0.0

1.0

2.0

3.0

4.0

5.0

6.0

Reference

Action Item #1-A