Basic Training 4th Annual ICP Conference

Iodine in biologicals

3 – Sample Measurement Optical Emission or Mass Spec?

ICP-OES

ICP-MS

1. Detection limits (Method) 2. Matrix (simple) 3. Wavelengths / Masses 4. Standard compatibility

IDL (50 ppb) * 10x = 500 ppb MDL

IDL (2 ppb) * 10x = 20 ppb MDL

good options

monoisotopic, few interferences

N/A

N/A

Dilution factors – can be low (5-20x), as sample mostly water, C, N

ICP-MS good choice due to simple matrix and good sensitivity

Summary

Step 1. Planning a. Required detection limits and uncertainty b. Chemical composition of sample Step 2. Sampling Step 3. Sample preparation Step 4. Sample measurement: ICP-OES or MS ? Effective and efficient approach with reasonable expectations