AOAC SPIFAN Stakeholder Program Meeting Book (March 17, 2021)

A2 Milk Business

X Expected to hit 14B in 2025 and 25B in 2030

# baby food launches with A2 milk protein

25

20

15

10

5

0

Oct 2017 - Sep 2018

Oct 2018 - Sep 2019

Oct 2019 - Sep 2020

Marketresearchfuture Precedence Research Mintel

Beta-Casein Background

X 30% milk protein is beta-casein (209 amino acid, ~ 24kDa)

X 12 beta-casein genetic variants 1 :

X A2-type: A2 (original), A3, D, E, H1, H2, I

X A1-type: A1, B, C, F, G

X Under gut digestion 2

X A1-type releases beta-casomorphin-7 (BCM-7, bioactive opioid peptide)

X A2-type releases much less or minimal BCM-7

1. Farrell, H. M. et al. (2004) J. Dairy Sci. 87:1641–1674 2. Jinsmaa Y, Yoshikawa M (1999) Peptides 20:957–962.; Hartwig et al. (1997) IDF Issue no. 9702 .DPLĔVNL HW DO J Appl Genet 48:189–198.