SPSFAM_Sugar_ERP-92018Proposal

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c. pharmacokinetic studies of with stable isotope-labeled compounds) experiments.in in vitro experiments including enzyme kinetics (CYP450 induction/inhibition, esterases and Phase II enzymes) studies allergen assay, and d. Excellent skills of animal husbandry (rats, mice, rabbits and minipigs, etc), dosing, necropsy and simple surgery. 9. Proficiency in software a. Software for analytical instruments (esp. mass spec): Analyst, Xcaliber, MassHunter, Empower, ChemStation, etc; b. AcslX ® (PBPK modeling); WinNonlin ® (pharmacokinetics), SigmaPlot ® and Prism ® (data presentation); c. QIMacros and R (statistics); ChemBioOffice (chemistry); d. EndNote, Reference Manager and RefWorks (bibliography), in addition to Microsoft Office Products. PUBLICATIONS Journal Articles:  N. Chamkasem, S. Lee , T. Harmon (2016) Analysis of 19 PCB congeners in catfish tissue using a modified QuEChERS method with GC–MS/MS. Food Chemistry. 192 : 900-906.  S. Lee , Y. Morris, L. Gross, E. Porter, F. Ortiz-Colon, J. Farrow, A. Waqar, E. Phifer, and K. Kerdahi (2016) Development and single-lab validation of an UHPLC-APCI-MS/MS method for vitamin K 1 in infant formulas and other nutritional formulas. Journal of Regulatory Science. 2 : 13-18.  N. Chamkasem, L. Ollis, T. Harmon, S. Lee , and G. Mercer (2013) Analysis of 136 pesticides in avocado using a modified QuEChERS method with LC-MS/MS and GC-MS/MS. Journal of Agricultural and Food Chemistry. 61 :2315-2329.  S. Lee, T. Poet, J. Smith, A. Busby-Hjerpe, R. Gunawan, and C. Timchalk (2011) Impact of repeated nicotine and alcohol coexposure on in vitro and in vivo chlorpyrifos dosimetry and cholinesterase inhibition. Journal of Toxicology and Environmental Health, Part A: Current Issues, 74 :1334-1350.  S. Lee, T. Poet, J. Smith, A. Busby-Hjerpe, and C. Timchalk (2010) Effect of in vivo Nicotine on Chlorpyrifos Pharmacokinetics and Pharmacodynamics in Rats. Chemico-Biological Interactions , 184 :449-457.  A. Busby-Hjerpe, J. Campbell, J. Smith, S. Lee , T. Poet, D. Barr, C. Timchalk (2010) Comparative Pharmacokinetics of Chlorpyrifos versus its Major Metabolites Following Oral Administration in the Rat. Toxicology , 268 :55-63.  J. Smith, J. Campbell, A. Busby-Hjerpe, S. Lee , T. Poet, D. Barr, and C. Timchalk (2009) Comparative Chlorpyrifos Pharmacokinetics via Multiple Routes of Exposure and Vehicles of Administration in the Adult Rat. Toxicology , 261 :47-58.  S. Lee , A. Busby, C. Timchalk, and T. Poet (2009) Effect of Nicotine Exposure on In Vitro Metabolism of Chlorpyrifos in Sprague-Dawley Male Rats. Journal of Toxicology and Environmental Health, Part A: Current Issues, 72 :74-82.  A. Mirfazaelian, K. Kim, S. Lee , H. Kim, J. Bruckner and J. Fisher (2007) Organ Growth Functions in maturing male Sprague- Dawley Rats. Journal of Toxicology and Environmental Health, Part A: Current Issues 70 :429-438.  Y. Choi, H. Choo, Y. Chong, S Lee , S. Olgen, R. Schinazi and C. Chu (2002) Synthesis and potent anti-HIV activity of L-2',3'- Didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine. Organic Letters 4 :305-307. Book Chapters:  C. Timchalk, J. Smith, A. Hjerpe, T. Poet, and S. Lee (2012) Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat (Chapter 13) in ‘ Parameters for Pesticide QSAR and PBPK/PD models for Human Risk Assessment ’, ACS Symposium Series, Vol. 1099 , J. Knaak et. al (ed.), pp. 195-213. American Chemical Society, Washington, D.C., DOI: 10.1021/bk-2012-1099, ISBN13: 9780841226456. FDA Laboratory Information Bulletins (LIBs):  E. Clevenger, S. Lee , B. Hawes, J. Oliver, J. Farrow, A. Irwin, A. Waqar, F. Ortiz and E. Phifer (2017) Determination of Crude Protein Content in Diverse Standard Reference Materials Using the Dumas Combustion Method ( accepted )  S. Lee, L. Gross, B. Rivera, C. Romero, B. Hawes, D. Lutrell, A. Waqar, A. Irwin, J. Farrow and E. Phifer (2015) A rapid UHPLC- MS/MS method for the quantitation of key monosaccharides, disaccharides and polyols in diverse food products.  S. Lee , Y. Morris, L. Gross, E. Porter, F. Ortiz-Colon, J. Farrow, A. Waqar, E. Phifer and K. Kerdahi (2013) Development and Validation of an UHPLC-APCI-MS/MS Method for Vitamin K 1 in Infant Formulas and Other Nutritional Formulas.  E. Porter, S. Lee , Y. Morris, J. Farrow, A. Waqar, T. Harmon, E. Phifer, and K. Kerdahi (2012) Qualitative Profiling of Triacylglycerides and Fatty Acid Methyl Esters to Detect Adulteration in Extra Virgin Olive Oil.

Sookwang Lee, Ph.D., D.A.B.T.