36 Rendu-Osler Weber Disease (Rowd)

678 Rendu-Osler Weber Disease

useful modality in the management of epistaxis in Rendu Osler disease" in comparison with their own results showing that out of only 15 patients evaluable for analysis, 13 had presented with recurrent secondary epistaxis. Nevertheless, it looks interesting to focus on the delay for recurrences, which ranged from 6 to 178 months. In the Gustave-Roussy experience (1) of about 35 patients we have observed 70% of cases without recurrence during the first year after treatment. Another publication coming from Pizzi et al.(6) showed that 4 out of 9 patients had a complete remission in 4/9 patients. 12 References 1. Gerbaulet A, Haie-Meder C, Breton C, et al. Role of LDR brachytherapy in Rendu-Osler disease. Radiother Oncol 1999; 53 (Suppl 1) abstract 35. 2. Maylin C. Benign conditions: Osler-Rendu-Weber disease. In Pierquin B, Wilson F, Chassagne D (eds.). Modern brachytherapy . New York-Paris: Masson 1987; 169-7. 3. Osler W. On a family form of recurring epistaxis associated with multiple telangectasia of the skin and mucous membranes. Bull John Hopkins Hosp 1901; 12 : 333-7. 4. Pierquin J, Richard G, Pierquin B. Une méthode de traitement de la maladie de Rendu-Osler par la radiothérapie. J Radiot Electrol 1951; 32 : 787-8. 5. Pierquin B, Koskas Y, Chassagne D. La plésiocuriethérapie endo-nasale de la maladie de Rendu-Osler par iridium 192. Ann Oto-Laryng 1969; 86 (3) : 127-32. 6. Pizzi G, Turcato G, Polico R, et al. La brachiterapia dell’epistassi nel morbo di Rendu-Osler. Indicazioni, tecnica, risultati. Radiol Med 1995; 89 : 861-4 7. Pohar S, Mazeron J-J, Ghilezan M et al. Management of epistaxis in Rendu-Osler disease: is brachytherapy effective? Int J Radiat Oncol Biol Phys 1993; 27 : 1073-7. 8. Weber FP. Multiple hereditary developmental angiomata (telangectasia) of the skin and mucous membranes associated with recurring hemorrages. Lancet 1907; 2 : 160-2.

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