ESTRO PT 2018

DNA repair: Non-homologeous endjoining (NHEJ)

Double Strand Break (DBS)

Exposed ends of the DNA strands are detected by the KU70–KU80 heterodimer Fast repair, can be error-prone !!! DNA-dependent protein kinase ( DNA-PKcs ) stabilize broken ends The heterodimer XRCC4/Ligase IV subsequently assists in repairing the break Loss of complete sequences of bases possible

DNA-PK

Ku70

Ku70

Ku80

Ku80

XRCC

Ligase