paediatrics Brussels 17

Treatment of Posterior Fossa Ependymoma Subgroups

age and subgroup interaction and a restricted cubic spline function with three knots for age to allow for a nonlinear relationship. All P values reported are two-sided. All statistical analyses were performed in the R statistical environment (v3.1.2), using R packages of survival (v2.37-7), rms (4.3-1), Coxphf (v1.1), and ggplot2 (v1.0.0).

A

B

GENE Cohort

St Jude’s Cohort

50

20

40

15

30

10

20

Age (years)

Age (years)

5

10

0

0

EPN_PFA

EPN_PFB

EPN_PFA

EPN_PFB

Subgroup

Subgroup

C

D

CERN Cohort

Burdenko Cohort

60

60

50

50

40

40

30

30

20

20

Age (years)

Age (years)

10

10

0

0

EPN_PFA

EPN_PFB

EPN_PFA

EPN_PFB

Subgroup

Subgroup

E

100%

80%

60%

40%

EPN_PFA EPN_PFB

Patients (%) 20%

0%

0–4

5–9

10–17

18+

Age Group (years)

Fig A1. (A-D) Boxplots of the age distribution of EPN_PFA and EPN_PFB, where boxes represent median and interquartile range and whiskers represent 95% CIs. (E) Proportion of patients with EPN_PFA and EPN_PFB in each age group. CERN, Collaborative Ependymoma Research Network; GENE, Global Ependymoma Network of Excellence.

© 2016 by American Society of Clinical Oncology

www.jco.org

from 139.18.224.1 Information downloaded from jco.ascopubs.org and provided by at UNIVERSITAETSKLINIKUM LEIPZIG on June 20, 2016 Copyright © 2016 American S ciety of Clinical Oncology. All rights reserved.