paediatrics Brussels 17

Ramaswamy et al

B

A

Univariate

Univariate

All GENE CERN

All GENE CERN

St Jude’s Burdenko

St Jude’s Burdenko

Age adjusted

Age adjusted

Multivariable

Multivariable

0.50 8.0 Hazard Ratio [EPN_PFA v EPN_PFB] for PFS 1.0 2.0 4.0

0.50 1.0 2.0 4.0 8.0 16.0 32.0 Hazard Ratio [EPN_PFA v EPN_PFB] for OS

Fig A2. Forest plots of EPN_PFA versus EPN_PFB across all cohorts and each cohort individually as a univariate analysis, age-adjusted univariate analysis, and multivariable analysis for (A) progression-free survival (PFS) and (B) overall survival (OS). CERN, Collaborative Ependymoma Research Network; GENE, Global Epen- dymoma Network of Excellence.

A

B

Log relative hazard based on Cox model: OS

Log relative hazard based on Cox model: PFS

2

2

1

PFA

0

PFA

0

−1

PFB

−2

Log Relative Hazard −2

PFB

Log Relative Hazard −3

0 10 20 30 40 50

0 10 20 30 40 50

Age (years)

Age (years)

Fig A3. Plot of age at diagnosis as a function of the log10 of the hazard ratios of EPN_PFA versus EPN_PFB for (A) progression-free survival (PFS) and (B) overall survival (OS).

J OURNAL OF C LINICAL O NCOLOGY

© 2016 by American Society of Clinical Oncology

from 139.18.224.1 Information downloaded from jco.ascopubs.org and provided by at UNIVERSITAETSKLINIKUM LEIPZIG on June 20, 2016 Copyright © 2016 American S ciety of Clinical Oncology. All rights reserved.